Quality Control in the ER: Misfolded Prohormones Get a Checkup
نویسندگان
چکیده
منابع مشابه
Misfolded proteins are sorted by a sequential checkpoint mechanism of ER quality control
Misfolded proteins retained in the endoplasmic reticulum (ER) are degraded by the ER-associated degradation pathway. The mechanisms used to sort them from correctly folded proteins remain unclear. Analysis of substrates with defined folded and misfolded domains has revealed a system of sequential checkpoints that recognize topologically distinct domains of polypeptides. The first checkpoint exa...
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unfolded substrate into the active site. Proteasomes The endoplasmic reticulum (ER) is the port of entry of are abundant in the cytoplasm and nucleus, but are membrane and secretory proteins into the central vacuapparently absent from the ER lumen. olar system, which includes the ER itself, the Golgi appaMutations in the cystic fibrosis transmembrane conratus, lysosomes, endosomes, the plasma m...
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ژورنال
عنوان ژورنال: Molecular Cell
سال: 2019
ISSN: 1097-2765
DOI: 10.1016/j.molcel.2019.07.020